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Crhr2 may be a novel drug target for heart failure
Crhr2 may be a novel drug target for heart failureA team of researchers from Japan, Germany, and the USA has identified a receptor protein on heart cells that may cause chronic heart dysfunction. Published in The Journal of Experimental Medicine, the finding suggests th...
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HIV vaccine design has made breakthrough progress
HIV vaccine design has made breakthrough progressA team of researchers from The Scripps Research Institute (TSRI) has designed a new immunogen based on the structures of the envelope glycoprotein from a common HIV subtype, HIV-C. This immunogen may aid in developing a ...
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Removing Tudor-SN delays cancer cell growth
Removing Tudor-SN delays cancer cell growthA protein called Tudor-SN is associated with the preparatory phase of the cell division, according to a study published online today in the journal Science. The study, led by the University of Rochester, Rutgers Universi...
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Discovery of novel CARM1 targets is hoped to facilitate the development of new therapeutics for breast cancer
Discovery of novel CARM1 targets is hoped to facilitate the development of new therapeutics for breast cancerUsing a quantitative mass spectrometry approach, researchers at the University of Wisconsin – Madison have globally profiled the protein targets of CARM1 in breast cancer. CARM1, a methyltransferase, has long been impl...
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Inhibition of GRP78 may impede development of pancreatic cancer
Inhibition of GRP78 may impede development of pancreatic cancerScientists at the University of Southern California (USC) have shed light on pancreatic tumorigenesis. Published in the latest issue of the Proceedings of the National Academy of Sciences, the study describes an approach...
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An existing antibiotic may improve TB treatment
An existing antibiotic may improve TB treatmentTuberculosis (TB) and human immunodeficiency virus (HIV) are both global epidemics that claim many people's lives each year. The bacterium Mycobacterium tuberculosis (Mtb) is the cause agent of TB. According to the Cente...
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A drug called BEZ235 may help fight against influenza
A drug called BEZ235 may help fight against influenzaResearchers from the St. Jude Children's Research Hospital and the University of Tennessee Health Science Center have developed an approach to fight against influenza, or called the flu. Influenza is quite prevalent w...
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Study identifies a previously unknown role of PD-L1 in cancer
Study identifies a previously unknown role of PD-L1 in cancerImmunotherapy has emerged as an important treatment for cancer patients. It uses substances that restore or enhance the immune system's natural ability to fight cancer. However, clinicians note a variety of side effects ...
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Fragment of C3 amplifies anti-tumor responses
Fragment of C3 amplifies anti-tumor responsesA team of researchers from the University of Michigan, UCLA, The University of Georgia, and Harvard Medical School has found that free C3d, a fragment of the protein C3 (complement component 3), enhances anti-tumor respo...
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Manipulating DNA repair response is a promising therapeutic strategy for immune diseases
Manipulating DNA repair response is a promising therapeutic strategy for immune diseasesTherapeutic immune suppression is an important treatment strategy for many immune conditions, such as autoimmune disorders, immunoregulatory disorders, and in transplantation. Sine immune pathways typically have essentia...
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TIAM1 predicts outcome of patients with neuroblastoma
TIAM1 predicts outcome of patients with neuroblastomaA team of researchers led by Jaime Font de Mora from Instituto de Investigación Sanitaria La Fe has identified a molecular target that may improve the outcome of patients with neuroblastoma (NB), the most common cancer ...
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Study sheds light on the mechanism of epilepsy and intellectual disability
Study sheds light on the mechanism of epilepsy and intellectual disabilityIntellectual disability (ID), once called mental retardation, is a generalized neurodevelopmental disorder characterized by limitations in intellectual functioning and in adaptive behavior. ID is estimated to affect 2-3%...
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Anti-LAP antibody helps kill cancer cells
Anti-LAP antibody helps kill cancer cellsScientists studying multiple sclerosis have stumbled upon a finding that a specific antibody enhances antitumor immune responses in several types of cancer. The study, led by Howard Weiner at Harvard Medical School and p...
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Novel approach to combating MERS-CoV
Novel approach to combating MERS-CoVResearchers from Canada and the Netherlands have developed a novel approach to combating a coronavirus named MERS-CoV, the cause agent of Middle East respiratory syndrome (MERS). MERS is a viral respiratory illness th...
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Antibody drug conjugate may tackle drug-resistant ALL
Antibody drug conjugate may tackle drug-resistant ALLA collaborative team has found a new way to treat acute lymphoblastic leukemia (ALL), the most common form of cancer among children. The study, conducted by investigators from the University of Manchester in the UK, T...
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Scientists identify a genetic variant that confers resistance to malaria
Scientists identify a genetic variant that confers resistance to malariaA team of researchers from the UK, the USA, the Gambia, Burkina Faso, Italy, Cameroon, Kenya, Tanzania, and Malawi recently has identified a genetic variant that reduces the risk of severe malaria by 40%. The finding may...
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Research reveals protective role of CD14 in IBD
Research reveals protective role of CD14 in IBDResearchers at Hannover Medical School, along with those from the University of Erlangen-Nürnberg, have found that the CD14 protein appears to play a protective role in the development of inflammatory bowel disease (IBD...
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Three specific proteins predict the risk of diabetic nephropathy
Three specific proteins predict the risk of diabetic nephropathyDiabetes can cause a wide range of complications such as retinopathy, neuropathy, and nephropathy, which are responsible for considerable morbidity. Diabetic nephropathy, also known as diabetic kidney disease, is a frequ...
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