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The biological mechanism of antitumor activity of natural product
The biological mechanism of antitumor activity of natural productNatural product is a major source of innovative drugs, it is an important tool of molecular biomedical research. At present more than 50% of the clinical application of drugs are directly or indirectly derived from natur...
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Implications of post-translational modifications of IRF7
Implications of post-translational modifications of IRF7A team of researchers led by FDA principal investigator has identified that IRF7 is a member of the antiviral drug restrictive issue family of transcription factors. IRF7 plays an important role in the transcriptional ac...
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Why do some people with immunity against HIV-1?
Why do some people with immunity against HIV-1?University of Minnesota researchers have found that HIV-1 armor gap, at least in part, explain the puzzling and may help develop new treatments. T lymphocytes in HIV-1 invasion, hijacking these cells produce more HIV, an...
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The biological significance of CSPG4
The biological significance of CSPG4A study by a Wayne State University found that CSPG4 is a transmembrane proteoglycan as an immunogenic growth substance on the surface of skin cancer cells, is related to skin cancer growth formation and poor prognosis i...
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An unusual hormone
An unusual hormoneResearchers from the University of Michigan have discovered a previously unknown hormone serves as a messenger between fat cells and the liver, and to explore the possibility of developing a new method of treatment of me...
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New blood vessel for islet regeneration
New blood vessel for islet regenerationA new study published in the journal PNAS shows that young capillaries can make aging islet renewed vigor. Blood sugar regulation will increase with age up and degraded, and age-dependent impaired glucose regulation will...
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Depletion of intrinsic expression of IL-8
Depletion of intrinsic expression of IL-8A team of researchers from Caltech has discovered IL-8 as a precursor amide of 99 amino acids long which then undergoes cleavage to make many active IL-8 isoforms. In culture, a seventy two aminoalkanoic acid amide is th...
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Dual role of key signaling pathways in cancer
Dual role of key signaling pathways in cancerA team of researchers demonstrated a key role in cancer signaling pathways known important in the formation of type 2 diabetes also play an important role. The results illustrate a class of long-term diabetes drug: thiaz...
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An important functional mapping of RRF
An important functional mapping of RRFNew findings by a Johns Hopkins University-led team reveal details about Ribosome-recycling factor(RRF), it is a protein found in microorganism cells such as eukaryotic organelles, specifically mitochondria and chloropla...
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Revolutionary technology for creating new drugs
Revolutionary technology for creating new drugsResearchers from the Australian National University have developed a revolutionary technology, which can produce a natural chemical substance used to assemble a rare anti-inflammatory drug used to treat cancer and malari...
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A new prognosis marker for the pharyngeal cancer: SIP1
A new prognosis marker for the pharyngeal cancer: SIP1According to a study from the University of Eastern Finland confirmed: SIP1 protein expression in pharyngeal squamous cell carcinoma tumors often precedes an advanced tumor stage, a high risk of recurrence and poor progn...
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Milestone breakthrough research on IL-4
Milestone breakthrough research on IL-4A new study by a Florida State University biologist shows that IL-4 is a protein that induces differentiation of naive helper T cells to Th2 cells. Upon activation by IL-4, Th2 cells after produce IL-4 in a feedback loop...
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A new kidney gene can regulate the blood pressure
A new kidney gene can regulate the blood pressureRecent experiments from University of Cincinnati researchers have found a large number of genes present in the kidney may play a role in the regulation of blood pressure and hypertension. KAP only abound in the renal pro...
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Central Role for Interleukin-2
Central Role for Interleukin-2According to a study led by researchers from Icahn School of Medicine, IL-2 is an interleukin, it's a part of the body's natural response to microbial infection. IL-2 mediates its effects by binding to IL-2 receptors, th...
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A stem cell can inhibit the development of a bad immune cell
A stem cell can inhibit the development of a bad immune cellImmune cells have been able to prevent human exposure to pathogen attack, but some "bad immune cells" attack the body's own tissue, leading to autologous rheumatoid arthritis and type 1 diabetes and other autoimmune dise...
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The breakthrough of cancer diagnosis and treatment: exosome study
The breakthrough of cancer diagnosis and treatment: exosome studyExosome is a cell through the "endocytosis - Fusion - efflux" a series of regulatory processes and the formation of extracellular nanoscale vesicles. Exosome can carry proteins, transported RNA, cellular material, and be...
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Where is the cellular localization of gastric inhibitory polypeptide?
Where is the cellular localization of gastric inhibitory polypeptide?Researchers at the University of Missouri reported that gastric inhibitory polypeptide is a 153-amino acid proprotein as a 42-amino acid amide. It's synthesized by K cells found in the tissue layer of the small intestine...
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A new method to combat chronic myelogenous leukemia
A new method to combat chronic myelogenous leukemiaCurrently, the scientists from Swiss Federal Institute of Technology have discovered an alternative Abl kinase, the drug can bind and act on this kinase, but has a low risk of resistance. Chronic myeloid leukemia, compri...
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