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Researchers find an inhibitor that suppresses stemness of glioblastoma cells
Researchers find an inhibitor that suppresses stemness of glioblastoma cellsThe protein PTPRZ can be a drug target for glioblastoma, and pharmacological inhibition of PTPRZ suppresses the stemness and tumorigenicity of glioblastoma cells in vitro and in vivo. These are the findings of a new stud...
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A study by Tsinghua University may reduce the side effects of radiotherapy
A study by Tsinghua University may reduce the side effects of radiotherapyRadiotherapy, one of the many therapies available to combat cancer, is highly effective in terms of high tumor control and functional preservation of diseased organs. Half of all cancer patients receive radiotherapy at s...
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Novel way to develop therapeutics for schizophrenia
Novel way to develop therapeutics for schizophreniaA study, outlined in the journal Molecular Psychiatry, has identified a potential way to develop therapeutics for schizophrenia and related disorders. The study was led by Prof. George Baillie at the University of Glasgo...
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Mutations increase children's susceptibility to viral respiratory infections
Mutations increase children's susceptibility to viral respiratory infectionsA research led by Jacques Fellay at école Polytechnique Fédérale de Lausanne in Switzerland has identified genetic mutations that increase children's susceptibility to respiratory infections. Fellay and colleagues hav...
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Research helps explain why obese people have worsening asthma symptoms
Research helps explain why obese people have worsening asthma symptomsA group of scientists from Duke University Medical Center, University of Arizona, University of Vermont, and Mayo Clinic Arizona have found a possible explanation of why obese asthmatic patients have more intractable sym...
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Drugs that target RIPK1 may treat inflammatory skin diseases
Drugs that target RIPK1 may treat inflammatory skin diseasesA study of the University of Melbourne has demonstrated a role of the protein RIPK1 in skin inflammation. The finding brings new hope for the treatment of inflammatory skin diseases. The study, titled "Inhibitor of Ap...
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DKK3 protein found to protect against atherosclerosis
DKK3 protein found to protect against atherosclerosisDescribed 11 July 2017 in Circulation, a study led by an international research team has shown that a cytokine-like protein DKK3 provides protection against atherosclerosis. Accordingly, the protein DKK3 is considered a ...
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New insights into the mechanism underlying lupus
New insights into the mechanism underlying lupusA study, led by Betty Diamond at the Feinstein Institute for Medical Research, has uncovered a mechanism underlying lupus, a systemic autoimmune disease characterized by abnormal immune responses leading to autoantibody ...
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Study extends the understanding of the link between telomeres and mitochondria
Study extends the understanding of the link between telomeres and mitochondriaAn international team of researchers from Germany, France, Singapore, and Australia has uncovered how the ZBTB48 protein functions to regulate telomeres and mitochondria. Findings of the study, which appear online in EMB...
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Research identifies a predictor of chronic rejection after lung transplantation
Research identifies a predictor of chronic rejection after lung transplantationScientists have found that a protein called ZBTB7A may be an early predictor of graft rejection after lung transplantation. The study, described in the journal Science Translational Medicine, could open a way for the dia...
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BMTP-11 found to delay progression of osteosarcoma
BMTP-11 found to delay progression of osteosarcomaOsteosarcoma is a rare but aggressive tumor that affects the bone. The overall incidence of osteosarcoma is low. But it is the most frequent cause of cancer mortality among children and young adults. If osteosarcoma is l...
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Plasma THBS2 level may improve early diagnosis of pancreatic cancer
Plasma THBS2 level may improve early diagnosis of pancreatic cancerA team of researchers, headed by Dr. Kenneth Zaret from the University of Pennsylvania, has found that detection of two proteins, THBS2 and CA19-9, may facilitate the diagnosis of early stages of pancreatic cancer, a dis...
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Preexisting antibodies prevent congenital CMV infection in monkeys
Preexisting antibodies prevent congenital CMV infection in monkeysCytomegalovirus (CMV) is one of the eight herpesviruses that commonly infect humans. Like other herpesviruses, CMV has the ability to remain dormant within the body for a while and may reactivate later. About half of all...
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SERA5 protein regulates the egress of malaria parasites from red blood cells
SERA5 protein regulates the egress of malaria parasites from red blood cellsMalaria is a mosquito-borne disease caused by protozoan parasites of the genus Plasmodium. This disease affects both humans and animals. Numerous efforts have been made to reduce its incidence rate and mortality rate, an...
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Epac2A protein regulates insulin secretion by beta cells
Epac2A protein regulates insulin secretion by beta cellsBeta cells (β cells) are specialized cells situated in the pancreatic islets of the pancreas, and are the cells responsible for the production and secretion of insulin, the most important peptide hormone for controlling...
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Rochester study: latent HHV-6 infection contributes to multiple sclerosis
Rochester study: latent HHV-6 infection contributes to multiple sclerosisThere is a long-standing assumption that viral infections are associated with demyelinating diseases such as multiple sclerosis, but the exact mechanism by which viral infections contribute to these diseases remains larg...
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Scientists find a way to prevent bone fragility in diabetes
Scientists find a way to prevent bone fragility in diabetesDiabetes mellitus is a group of metabolic disorders that are characterized by hyperglycemia. There are two major types of diabetes mellitus, type 1 and type 2. The most common form of diabetes in the general population i...
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Research offers a new way for developing TB drugs
Research offers a new way for developing TB drugsMycobacterium tuberculosis (Mtb) is the bacterium that causes the serious disease tuberculosis (TB). This pathogen infects about 1.5 billion individuals around the world and carries away 1 million of lives annually. The ...
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